I've wanted to try LMDE on a HDD install for a long time, but it never quite worked with the recently "deceased" MacBook or with the iMac.
Now, with a new laptop, I've installed LMDE 201303 RC Cinnamon 64-bit. The install was quick; it boots very quickly; and I've experienced no major problems since installing. I have noticed the following issues, some of which others also have pointed out on different threads:
1.) System freeze: I only experienced one freeze while setting up apps and tweaking: too much multitasking?
2.) Printer set-up: The app didn't work for me, but it also didn't work well with LM Nadia either. FWIW, it worked "out of the box" with Debian-based CrunchBang . As it is, I prefer to install my printers with Unix Printing System (127.0.0.1:631), which always finds the printers and the drivers.
3.) Chromium: In LMDE, doesn't sync well with Chrome/Chromium on the iMac. A message notes that the others are newer versions, so I have to remove and reinstall the sync option each time. I've removed Chrome via Synaptic and also deleted it in other folders, but it still appears in the menu but doesn't load. I also installed Chrome as a test, but it doesn't appear at all in the menu. Fortunately, there is Firefox and Opera.
4.) Fonts: They don't seem as crisp as in LM Nadia Cinnamon--especially serif fonts--but I've seen worse with other distros.
5.) Software Manager vs. Synaptic Package Manager: If you're relying on Debian repositories, do you really need both? While trying to resolve the issues with Chromium and Chrome, I tried both but Software Manager seemed buggy and would not open Chromium to install it. Moreover, perhaps I'm wrong about this, but it seems that CrunchBang, for example, has more up-to-date ppas when I installed software in Synaptic.
Overall, I like LMDE Cinnamon and think the LMDE team has done a great job with it. I look forward the the stable version and will stick with 201303 RC in the interim.
System 76 Pangolin: 4x Intel(R) Core(TM) i5-3230M CPU @ 2.60GHz, Fedora 21 Cinnamon 64-bit
iMac 21.5: Intel Core 2 Duo 3.06 GHz, dual boot Mac OS 10.6.9 and LMDE Cinnamon 64-bit
It's never too late to learn something new.