If you haven't already, run winecfg from a terminal. This will open up the wine configuration tool where you can configure many of the settings in wine. There is an option to autodetect drives. Hope that helps.
I have wine running on Linux Mint (Barbara) I am re-playing Deus Ex, so I can confirm that it works as advertised. First go here: http://www.tatanka.com.br/ies4linux/page/Main_Page and download the IEs4 script, it will make the whole process of running wine easier, additionally, there is a lot more help and info on wine here: http://frankscorner.org/ which may help you..