Mint 10 OK?
I have set it to use another partition as its /home, but realized this means that email and browser bookmarks or adding a music CD and all that when done on LMDE or LM10 will not be 'known' by the other. (I originally opted to use the same /home, but encountering a problem decided to make a completely new /home -- later discovered that /home content was not related to that [Solved] problem.)
Both are 64-bit, so that is not a factor. My belief is that using the same /home for all distros within the Debian branch is no problem, but letting both 32 and 64-bit variants write to it could be. But that is based on rumor (32/64) and only limited experience (LM8,9,10 all worked fine with only a few tiny cosmetic glitches)
I like what I saw when using LMDE, and will either reinstall with the old /home or, if someone can tell me how, reassign /home from sda6 to sda8.
For the record, running LM the first time made (I'll have say nearly) me as delighted as booting up an Amiga1000 the first time. The first WOW!! since the A3000 died.