I run LMDE on a PC connected to a 37" HDTV. I run the desktop at 1920x1080 and typically set all fonts in Preference > Appearance to between 20 and 24 px to be legible from the sofa.
After updating the other evening (to Mint10 menu, desktop, etc.) I find that the panels are not using the fonts that I selected above. They appear to be maybe 10-12 px and are impossible for me to read. The "Menu" text for mintMenu as well as the clock in the panel are tiny. Changes to Preference > Appearance seem not to apply anymore.