according to viewtopic.php?f=90&t=8400&p=52081 it should be able to. So long as you're not after anything too complicated, I guess it should work, but in some cases it might assume some components that ubuntu has that mint drops. If you encounter any problems, post them here and hopefully we'll be able to solve them.
If you have a question that has been answered and solved, then please edit your original post and put a [SOLVED] at the end of your subject header Hint - use a google search including the search term site:forums.linuxmint.com
Well, now I have tried, and yes, Uck can be used to customize Mint. I have customized, put the resulting Iso on a usb-stick, and installed to harddisk from it. Absolutely wonderful!! Installing from a usb-stick takes less than a quarter of an hour. (I did not time it, it might even be less than 10...)