I'd pull the battery, so as not to leave it on charge that long. For a laptop, heat is the only thing I can think of now that might be a problem, I think I would use a cooling pad if it stayed on that long.
When I had to use my netbook full time, only time I turned it off was on a road trip and when updating system files like the kernel.
-Acer Aspire One AO532h-Atom CPU-N450-1.66ghz
RAM- 2gbs-(Maya-Xfce) LInux 188.8.131.52-generic(i686)
-ASUSTek Computer INC. AMD Sempron 3200+ Nvidia GeForce 9500 GT- SB Audigy 2
RAM 3gbs- (Mint 13 Xfce - Mint 13 Mate) Linux 3.2.0-26-generic(i686)