Good advice above: the main thing is to get the BIOS set to make the USB drive the first priority for booting. BUT be aware that certain brands of thumb drive - e.g. Kingston DataTraveler - will NOT boot an operating system even if the computer's BIOS is set correctly as the priority. Kingston mentions this on its website, but it completely confused me until I found it. I reformatted etc. etc. etc. to try to make it work and it just won't. By comparison other drives - e.g. SanDisk - work fine.
Test driving Mint 17.1 Cinnamon via Persistent Live USB on a W7 Lenovo desktop with peripherals, and on a W10tp Dell laptop. Dual booting Mint 16 XFCE with W7 on an Acer netbook, testing Live M17 XFCE.