Yes, just install over the existing installation. It will save your home folder and settings. Select but do not format the partition, and set it as " / " from manual partitioning, and be sure to import documents and settings during the install questions. You will have to reinstall all of you programs from apt, but you will not lose the settings of customizations. But what ever you do, at least back up your home folder just in case. I just take a screen shot, and use it to put everything back in order. If you had a custom panel, just restart you computer when you reinstall every thing, and the launchers will all reappear.
The OS: Linux Mint Debian 64 KDE Plasma 4.10.5
The Hardware: Dell 17R Special Edition, Intel Quad Core, i7 - 3.40 GHz, 8 GB Ram, HD 1TB
Video NVIDIA GeForce GT 650M 2GB
The Name: Bob