I'd used Slackware, gentoo, Debian, Mandrake(now Mandriva) and built an LFS box in the past, I played with Daryna a few weeks ago and was hooked. Its got everything you need and the few things you don't have are in the package manager.
For a Desktop Linux system it blows Windows and other linux distros out of the water and is the only one to work out of the box with all 5 Desktop computers i own. its quite powerful and I havn't run across any major problems yet and I've been running it for a month.
Now, I still have trouble saying "best" distro because LFS and Slackware have been very kind to my server computers, but then again I like to start with a barebones system and compile what I need onto it, but they are certainly not for newbies or even many linux "gurus" as they are pretty much garanteed not to work out of the box with any computer unless you want a basic CLI with no additional applications. Adjusting Mint to work on those servers would nullify the purpose of Mint imo.
Best desktop distro, yes.
Best overall distro, I'm sorry, I'm still gonna have to give that honor to LFS, followed closely by slackware(depending on how much time i have to build the system)
P.S. I do not recommend jumping into either LFS or Slack unless you are confident with the CLI, know how to Bash script, have compiled ssome packages in the past and have a relatively deep understanding of which packages you use and which you don't, as well as package dependancies. Just stick with Mint, I know I will on my Desktops