I agree with things like swappiness, although I always set up it on my systems at 0, not 10, as on a desktop computer, you want swappiness to be as close to zero as possible. But vfs_cache_pressure = 1000?
Hmm, mine is always at 50 and no problem with "the desktop reactions", at the contrary.
To increase the speed of browsing files and folders again and again, we should decrease vfs_cache_pressure. Not sure there is a real need to touch to dirty_background_ratio and to dirty_ratio. You can find good advices here: Tales from responsivenessland: why Linux feels slow, and how to fix that
Problem, bug, with Liquorix kernel(s)?
In the link you give, we read:
There are a lot of complaints about the system being unresponsive when copying large files
Maybe also something to see with the file system. Try XFS and/or JFS instead ext4. I use them exclusively for a long time now and never had a problem like this one whatever the distro... At the contrary.
Just one example. On my 'test' PC, I use Mageia Cauldron (future Mageia 2). It is setup as I always do with vm.swappiness = 0 and vm.vfs_cache_pressure = 50. The / partition is JFS and /home is XFS. Well, there is absolutely no problem of "desktop reactions", system responsiveness or some problem copying large files. At the contrary. E.g. when I'm browsing files and folders, the system is quite fast and when I copy a large file like a 4 GB or more ISO or a quite big MKV file, more 5 GB at least, from a folder to another, well, the copy just takes some seconds...
K.I.S.S. ===> "Keep It Simple, Stupid"
"Simplicity is the ultimate sophistication." (Leonardo da Vinci)
"Everything should be made as simple as possible, but no simpler." (Albert Einstein)