If you decide to go with the Debian testing repos make sure that the very first thing you do is run;
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sudo apt-get update
and then;
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sudo apt-get install apt-listbugs
then you can run your package upgrade.
apt-listbugs will tell you of any KNOWN bugs out against any package you are upgrading or installing. As someone that runs Debian testing or Sid as my production OS I can tell you that this will save you a lot of problems. You can still get lucky and discover a NEW bug though.
Testing is pretty good at this point. Could change tomorrow. Personally I think Sid is running a bit better than testing right now as it is a bit ahead of testing on getting the packages. Seeing how, right now, Sid is where the bug fixes are tested before migrating the packages to testing It seems a bit more stable.
I usually use testing as my production OS but I am on Sid right now.
Do not try going from LMDE to Sid directly if that tempts you. Go to testing and make sure you are fully upgraded before even thinking about Sid. There will be enough change just going to testing.
Dell XPS 420 Core2 Quad Q 6600, audigy5.1, Radeon HD 6450 - currently 4 320Gb HDD, Debian Squeeze for secure use, Debian testing for daily use, Debian Sid for fun.