I have actually converted my LMDE2 to Devuan
Changed repos from LMDE's Debian ones to Devuan Jessie repos and done dist-upgrade. It went smooth and the system works fine (not that the original LMDE2 or Debian Jessie make a great desktop nowadays!)
The only things showing some problems are probably due to DBus; namely, the Indicator plugin on my desktop shows nothing, the OSD messages are shown more like tooltips, and closing my laptop lid does nothing although the Power manager was (and apparently still is) configured to bring it to standby when closed. Everything else works fine, including other power management functions, and I guess it wouldn't be much of a problem to tweak the unresponsive lid if I take the effort.
I must add this is actually not a "real" LMDE2 but an upgrade from LMDE1 - my primary desktop was and still is Xfce, which unfortunately got unsupported in LMDE2. When I look at it this way, probably this is more a Debian installation now which got upgraded to Devuan. Anyhow, it works quite nice.
I don't know how other desktop environments are tied to systemd, but I'd wholeheartedly recommend a future LMDE to be based on Devuan. I guess it would be the ONLY one I'd continue to use!